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New Links In The Cystic Fibrosis Chain Uncover Potential Therapeutics(Oct. 22, 2007) — Cystic fibrosis (CF) is an inherited disease caused by mutations in the CFTR gene. Each mutation has number of effects on the cells of the lungs. New evidence generated in vitro by Vojo Deretic and colleagues at the University of New Mexico School of Medicine, Albuquerque, has provided insight into the mechanisms by which one of these changes impacts both CF and the complications of CF. These data provide support for ongoing clinical trials and raise the possibility of new targets for the development of drugs to treat individuals with CF. CFTR mutations that cause CF make a compartment of the cell known as the TGN more acidic than it is in cells from healthy individuals. In this study, in vitro analysis revealed that hyperacidification of the TGN causes increased activity of a protein known as furin. Through increased production of a soluble factor known as TGF-beta this augmented the production of collagen (which in situ is associated with tissue fibrosis, a characteristic of damaged lung in individuals with CF) and suppressed the ability of human macrophages to kill the bacterium Pseudomonas aeruginosa, infection with which is a major complication for individuals with CF. This study provides strong support for the use of chloroquine (which counteracts high levels of TGN acidity) to treat CF, something that is currently being tested in clinical trials, and identifies furin inhibitors as potential new therapeutics for the treatment of CF. Article: Elevated furin levels in human cystic fibrosis cells result in hypersusceptibility to exotoxin A-induced cytotoxicity Adapted from materials provided by Journal of Clinical Investigation.
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 The Empire State Medical Association condemns the racist statement of Nobel Prize winner DNA authority of Dr. James Watson. (www.nyesma.org) Dr. James Watson made an appearance in London to promote his new book and apologized for his remarks, saying he did not mean to characterize Africans as genetically inferior, British media reported.
Brain Chemistry Linked To Aggressive Personality
New Links In The Cystic Fibrosis Chain Uncover Potential Therapeutics
Blocking Stress Protein Decreases Alzheimer's Peptide In Mice What's The Fat Content? Whether Or Not You Notice Depends On How You Think
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